|
KMID : 0385219980080020035
|
|
Korean Journal of Gerontology
1998 Volume.8 No. 2 p.35 ~ p.40
|
|
|
Mast-Cell-Derived TGF-β1 Serves as an Essential Anaphylactic Factor
|
|
Kim Hyung-Min
Kim Chang-Young
|
|
|
Abstract
|
|
|
|
TGF-β1 is a member of a family of polypeptide factors that control proliferation, differentiation, chemotaxis and other functions in many cell types. TGF-β1 has been shown to inhibit many immunologic functions. However, here we report that TGF-β1 has an important role on the elicitation of IgE-dependent allergic reactions. The synthetic antisense TGF-β1 oligonucleotides dose-dependently inhibit passive cutaneous anaphylaxis (PCA) reaction and histamine release from the mast cells activated by anti-DNP IgE in rats. The antisense TGF-β1 oligonucleotides also had a significant inhibitory effect on anti-DNP IgE-induced TNF-α release from mast cells. Additionally, neutralising antibody to TGF-β1 blocked the PCA reaction significantly, but its antibody did not inhibit peritoneal mast cells released histamine upon treatment with anti-DNP IgE. Our results suggest that TGF-β1 is critical to the development of IgE-dependent anaphylaxis reactions.
|
|
|
KEYWORD
|
|
|
TGF-β1, Mast cells, Anaphylaxis, Antisense TGF-β1 oligonucleotides
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|